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Research interests are in the area of patterning of the vertebrate embryo and limb development. This work is currently focussed on a mouse mutant, Dominant hemimelia, that exhibits hindlimb skeletal malformations similar to those that may be found in human infants. Research work is conducted on campus and at Massachusetts General Hospital. For further descriptions see Mus or DhMouse
Publications (maiden name Wesolowski):
Wesolowski, MH, Lyerla, TA. The developmental appearance of hexokinase and alcohol dehydrogenase in Xenopus laevis. J. Exp. Zool. 1980; 210:211-219.
Wesolowski, MH, Lyerla, TA. Alcohol dehydrogenase isozymes in the clawed frog, Xenopus laevis. Biochem. Genet. 1983; 21(9/10):1003-1017.
Sapirstein, VS, Stocchi, P, Wesolowski, M, Gilbert, JM. The characterization and biosynthesis of soluble and membrane-bound carbonic anhydrase in brain. J. Neurochem. 1983; 40(5):1251-1261.
Vishwanatha, JK, Coughlin, SA, Wesolowski-Owen, M, Baril, EF. A multiprotein form of DNA polymerase from Hela cells. Journal of Biological Chemistry 1986; 261(14):6619-6628.
Owen, MH, Holmes, LB. Stage and dose dependent effects of all-trans retinoic acid on expression of Dominant hemimelia in mice. Teratology 1998; 57(2):108.
Owen, MH, Holmes, LB. Restricted pattern of expression of tibia hypoplasia and reduced number of vertebrae produced by Dominant hemimelia. Teratology 1998; 57(2):107.
Morin, BJ, Owen, MH, Raumamurthy, GV, Holmes, LB. 1999. Pattern of skeletal malformations produced by Dominant hemimelia (Dh). Teratology 60(6): 348-355 (Owen, Corresponding Author)
